Identification of BST2 as a conjunctival epithelial stem/progenitor cell marker

Identification of BST2 as a conjunctival epithelial stem/progenitor cell marker

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Summary: The conjunctival epithelium consists of conjunctival epithelial cells and goblet cells derived from conjunctival epithelial stem/progenitor cells.However, the source of these cells is not well known because no specific markers for strikketøy oppbevaring conjunctival epithelial stem/progenitor cells have been discovered.Therefore, to identify conjunctival epithelial stem/progenitor cell markers, we performed single-cell RNA sequencing of a conjunctival epithelial cell population derived from human-induced pluripotent stem cells (hiPSCs).The following conjunctival epithelial markers were identified: BST2, SLC2A3, AGR2, TMEM54, OLR1, and TRIM29.Notably, BST2 was lock shock and barrel art strongly positive in the basal conjunctival epithelium, which is thought to be rich in stem/progenitor cells.

Moreover, BST2 was able to sort conjunctival epithelial stem/progenitor cells from hiPSC-derived ocular surface epithelial cell populations.BST2-positive cells were highly proliferative and capable of successfully generating conjunctival epithelial sheets containing goblet cells.In conclusion, BST2 has been identified as a specific marker of conjunctival epithelial stem/progenitor cells.